Study to Evaluate the Safety and Efficacy of Ciprofloxacin Inhaled in Patients With Cystic Fibrosis. To evaluate the change in forced expiratory volume FEV1 from baseline to Day between Cipro Inhale-treated and placebo-treated subjects after a 4-week treatment period. E-mail: [email protected]. Randomized, double-blind, placebo-controlled, multicenter study to evaluate the safety and efficacy of inhaled ciprofloxacin compared to placebo in subjects with cystic fibrosis. Freigeben Facebook Twitter LinkedIn. Zurück zu den Cystic fibrosis dating Trial Condition s : Zystische Fibrose Study to Evaluate the Safety and Efficacy of Ciprofloxacin Inhaled in Patients With Cystic Fibrosis. Bayer Identifier: EudraCT Number: View results Ask a Question. Cystic fibrosis dating Teilnahmebedingungen Geschlecht. Alter 12 Jahre Keine Begrenzung. Einschlusskriterien - Subjects, or their. Zusammenfassung der Studie Enrollment Goal Trial Dates May January Phase 2. Könnte ich ein Scheinmedikament erhalten? Products Ciprofloxacin DPI BAYQ Accepts Healthy Volunteers Nein. Wo Sie teilnehmen können Ladevorgang Ask a Question. Studienstandorte Studienstandorte. Studiendesign Randomized, double-blind, placebo-controlled, multicenter study to evaluate the safety and efficacy of inhaled ciprofloxacin compared to placebo in subjects with cystic fibrosis Trial Type : Interventional. Intervention Type : Drug. Trial Purpose : Treatment. Allocation : Randomized. Cystic fibrosis dating : Double Blind. Assignment : Parallel Assignment. Trial Arms : 4. Secondary Outcome Change from baseline in FEV1 at Visits 4, 5, and Follow-up Visits 8 and 9. Timeframe : Baseline and Visit 4 DayVisit 5 DayVisit 8 Dayand Visit 9 Day 56 Change from baseline in P. Timeframe : Baseline and Visit 4 DayVisit 5 DayVisit 7 DayVisit 8 Dayand Visit 9 Day 56 Change from baseline in forced vital capacity FVC at visits 4, 5, 7, 8 and 9. Number of participants developing ciprofloxacin-resistant mucoid P. Number of participants developing ciprofloxacin-resistant non-mucoid P. Effect of ciprofloxacin DPI treatment on quality of life measured by Cystic Fibrosis Quality of Life Questionnaire Revised CFQ-RRespiratory scale. Timeframe : Baseline and Visit 7 Day and Visit 9 Day 56
Drug therapies for reducing gastric acidity in people with cystic fibrosis
Thieme E-Journals - Seminars in Respiratory and Critical Care Medicine / Abstract Study to Evaluate the Safety and Efficacy of Ciprofloxacin (Inhaled) in Patients With Cystic Fibrosis date) - Ability to perform reproducible pulmonary. Unlocking the Secrets of Cystic Fibrosis: A Genetic Study of people with CF in Germany Date. Friday, October 20, Featured resource article. Drug therapies for reducing gastric acidity in people with cystic fibrosis - PMCDate Event Description 18 August New search has been performed A search of the Cystic Fibrosis and Genetic Disorders Group's Cystic Fibrosis Trials Register identified a single new reference to an already included trial DiMango This does not fulfil the inclusion of trials criteria. No withdrawals mentioned. This issue of Seminars in Respiratory and Critical Care Medicine reviews our current knowledge of key areas related to cystic fibrosis CF. It was decided by the review authors to remove the data analysis that was previously included within the review.
Zusammenfassung der Studie
Added value of this study. Study to Evaluate the Safety and Efficacy of Ciprofloxacin (Inhaled) in Patients With Cystic Fibrosis date) - Ability to perform reproducible pulmonary. Up to 24 weeks of treatment with elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) was efficacious and safe in patients with cystic fibrosis ≥12 years of age who. Friday, October 20, Featured resource article. Current CFTR modulator therapies, such as elexacaftor–tezacaftor–ivacaftor, have transformed cystic fibrosis care. Unlocking the Secrets of Cystic Fibrosis: A Genetic Study of people with CF in Germany Date.Faecal weight, fat absorption, weight and height changes, serum calcium, triglycerides, cholesterol, phosphate, iron, Hb, albumin, Crispin Norman score, Shwachman score. Topical corticosteroids are also commonly used. We examined the publications for potential reporting biases but were not able to compare the original trial protocols with the final publications. Studienstandorte University of Utah Medical Center Salt Lake City, United States, Studienstandorte Royal Children's Hospital Brisbane Brisbane, Australia, However, we were unable to group data into the time points we had originally planned and so report results narratively from the end of each trial. The included trial reported diarrhoea and abdominal discomfort as adverse effects in participants on the prostaglandin E2 analogue, enprostil treatment Heijerman Durie states that the participants were selected from a restricted geographical area in proximity to the hospital on the basis of an assessment by clinical personnel of their ability to perform a clinical study accurately at home Durie This trial measures gastric inhibitory polypeptide and insulin response in CF. In the trial, Heijerman reported the results for faecal fat excretion and found that there was no statistically significant difference between the treatment and control groups Heijerman Participants and investigators blinded to the results. However, the results from the combination of cimetidine and sodium bicarbonate were no better than those from cimetidine and sodium bicarbonate individually. Similar articles. This does not fulfil the objective of the review. We were not able to combine the results from these trials due to their design. Proton pump inhibitors and H2 receptor antagonists do this directly by inhibiting acid production from parietal cells. For binary outcome measures, the authors plan to calculate a pooled estimate of the treatment effect for each outcome across the studies, the odds of an outcome among treatment allocated participants to corresponding odds among controls. Outcomes Primary outcome measure: time to first exacerbation defined as initiation of treatment with IV or oral antibiotics for at least 7 days based on respiratory symptoms. Timeframe : Baseline and Visit 4 Day , Visit 5 Day , Visit 7 Day , Visit 8 Day , and Visit 9 Day 56 This is a randomised trial comparing the pharmacokinetics between different modes of delivery of famotidine, that is oral versus intravenous route. Studienstandorte Tufts-New England Medical Center Boston, United States, Auch topische Kortikosteroide werden häufig eingesetzt. Individual trials reported some improvements in abdominal pain and fat absorption. It was felt that this analysis was inappropriate and it would be of more benefit to the reader to report the individual trial results narratively under the relevant outcomes. Studienstandorte Georgia Health Sciences University Augusta, United States, From our review, no conclusive benefit of improved nutritional status and lung function can be deduced from the effects of agents that reduce gastric acidity. RSS-Feed abonnieren Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein. Studienstandorte Saint Barnabas Medical Center Livingston, United States, Studienstandorte The Prince Charles Hospital Chermside, Australia, Studienstandorte Austin Children's Chest Associates Austin, United States, All the trials were run in single centres and lasted from five days to six months. All the trials were run in single centres and duration ranged from five days to six months. Official websites use. Where between trial variability is not statistically significant we will carry out a fixed effect analysis and if the between trial heterogeneity is statistically significant we will perform a random effects analysis. We were unable to pool data from the trial by Chalmers because there were insufficient data to calculate the SD Chalmers Studienstandorte Children's Hospital and Regional Medical Center Seattle, United States,
